Amlodipine

Amlodipine tablets: from what help and under what pressure to take them?

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50-60% of the world’s inhabitants are diagnosed with hypertension after the age of 60 years. But the younger generation (up to 40 years old) is addressing complaints of blood pressure to therapists more and more often. The reasons for the occurrence of the disease are many: smoking, alcohol, sedentary lifestyle, etc. Doctors prescribe medications that lower blood pressure during treatment. Most often, their choice is Amlodipine, from what and how to apply it you will learn in our article.

Amlodipine-blood-pressure

Amlodipine: from what helps?

The drug affects the body in two ways: antianginal and hypotensive. The composition of the drug: amlodipine besylate, crospovidone, lactose monohydrate, povidone, calcium stearate. Available in the form of tablets of 5 and 10 mg.

Antianginal effect is the ability to stop, effectively prevent strokes by normalizing the work of the heart muscle, improving coronary blood flow. Hypotensive effect is a decrease in blood pressure by expanding the diameter of blood vessels, relieving spasms, leading to their narrowing.

The action of the drug is based on blocking slow calcium channels. Due to this, the transition of calcium ions to the structural elements of smooth muscle vessels is spiked. With an increase in the total amount of calcium ions, the muscles of the vessels decrease in size, the passage for the blood flow narrows, respectively, the blood pressure rises. The drug prevents the increase in vascular resistance, thickening of the walls of blood ducts, due to this, blood pressure is reduced. Hypotensive effect due to the control of the state of vascular smooth muscle. The length of the cells of the smooth muscle vessels increases, the lumen expands, the blood flows faster due to a decrease in duct resistance. Blood pressure decreases, the effect lasts for at least a day. Antianginal effects on the body occurs due to an increase in the patency of arteries and arterioles. The load on the heart decreases, the myocardium receives enough oxygen. This is especially important for angina and ischemia. The risk of coronary artery spasm is reduced. Ischemic heart disease requires special attention to blood pressure indicators. Amplodipine helps to reduce the degree of myocardial hypertrophy, cardioprotectrono and antiatherosclerotic effect on the vessels. The cardioprotective effect on the myocardium is due to the efficient delivery of oxygen and a decrease in the load on the heart. The action of the drug facilitates the condition of patients not only with coronary artery disease, but also its chronic form, reduces the risk of blood clots in atherosclerosis. Amplodipine does not violate the metabolism, so it is used to treat high blood pressure in asthmatics and diabetics. When receiving a daily dose of Amlodipine, patients with vasospastic angina pectoris noted a decrease in the need for nitroglycerin and other nitrates, a decrease in the number of seizures.

Indications for use

Amlodipine has a wide and effective use in the presence of the following diseases:

  • stenocardia;
  • vasospasm;
  • coronary heart disease;
  • non-ischemic cardiomyopathy;
  • bronchial asthma;
  • arterial hypertension;
  • angina of exertion.
Stop taking Amlodipine sharply impossible. Follow the jump and increase in blood pressure, increase the pulse. Dosage should be reduced within a few days.

Instructions.

In appointing the drug, therapists focus on the chronic diseases of patients, the clinical picture as a whole, age, weight.

Amlodipine for pressure and angina is administered in a dose of 5 mg. The amount of the drug is increased, depending on the patient’s condition, the tolerance of the active substance, but not more than 4 times for a single use.

There are several drug regimens: for hypertension, 2.5 to 5 mg daily is prescribed. Reception is single. At what pressure to take the drug, is decided by the doctor together with the patient. The best indicator is 140 -150 mm Hg. v .; For patients with impaired liver function, a separate regimen has been drawn up. As a sample, a dose of 5 mg is assigned, it is possible to increase to 10 mg with a positive result of the medication; in angina pectoris Amlodipine is prophylactic or therapeutic. With the prevention of 10 mg per day, in connection with the attacks and their treatment 5-10 mg; antianginal daily dose is 5 mg in patients of any age. Assigning the drug simultaneously with ACE inhibitors, diuretics, blockers, leave the dosage in the range of 5-10 mg.

It is impossible to arrest a sharp surge in pressure with this medicine. It is taken for prophylactic purposes in chronic diseases of the cardiovascular system, therapeutic – in the detection of coronary artery disease, hypertension. Separately, you should talk about overdose.
With self-dose increase and admission several times a day will require hospitalization of the patient. In the walls of the clinic, gastric lavage is performed, with the help of calcium gluconate, Dopamine, the heart and blood vessels are restored. For home remedy of dosage symptoms, use plentiful drink, vomiting, taking activated charcoal (1 tablet per 10 kg of weight). If the condition does not improve, call the emergency room. Patients with a weight of less than 40 kg and a low growth should be given a daily dose of Amlodipine not more than 2.5 mg.

Where to buy online?

Here You may Buy Amlodipine 10 mg online.

Side Effects

Any medication has side effects. Amlodipine tablets are no exception.

Common effects of taking medication for hypertension include:

  1. heart palpitations, shortness of breath;
  2. lowering the pressure to the minimum;
  3. fainting;
  4. swelling of the face;
  5. flushing to the skin of the face;
  6. asthenia;
  7. vasculitis;
  8. migraine,
  9. irregular heartbeat – are rare;
  10. headaches;
  11. drowsiness;
  12. dizziness;
  13. rapid fatigability even with slight physical exertion;
  14. depression, sleep disturbances are rare, occur in 1 out of a thousand patients;
  15. nervousness;
  16. anxiety;
  17. excessive sweating;
  18. nausea, vomiting;
  19. stomach pains;
  20. rarely, dry mouth, diarrhea or constipation, enlarged liver, bloating;
  21. pain when urinating;
  22. skin allergic reactions (itching, rash);
  23. impotence;
  24. decreased libido;
  25. angioedema;
  26. arthrosis;
  27. myalgia;
  28. arthralgia;
  29. rarely – myasthenia gravis;
  30. dermatitis, alopecia;
  31. rhinitis;
  32. convulsions;
  33. reduced vision;
  34. chills;
  35. tinnitus;
  36. lower back pain;
  37. nosebleeds.
In identifying the side effects of the drug on the patient’s body, the doctor selects Amlodipine analogues. This may be Biocom, Amplodin Farmak, etc.

During treatment, changes in the patient’s weight should be monitored. One of the side properties is the reduction or slight hanging of the patient’s body weight. It is necessary to adjust the diet and the amount of salt consumed. Amlodipine causes gum hyperplasia (the tissues of the oral cavity expand, cover the teeth). It is regularly visited by the dentist.

IT IS IMPORTANT TO KNOW! Shocking statistics! Hypertension is the most common disease of the cardiovascular system. With age, the prevalence of the disease increases and reaches 50-65%. In order not to bring to the complications and operations it is important to prevent the disease.

Contraindications

Caution should be taken when taking the drug in children under 16-18 years old, with myocardial infarction, arterial hypotension, aortic stenosis, mitral stenosis. Contraindications include: pregnancy and breastfeeding. Women of childbearing age should avoid unprotected sexual intercourse during treatment with Amlodipine, because its reception causes enormous harm to the development of the fetus during pregnancy. The active ingredient of the drug penetrates into breast milk, therefore, when prescribing a nursing mother, the child is transferred to artificial mixtures; cardiogenic shock; sensitivity to the components of the drug; unstable angina. In the presence of contraindications Amlodipine replaced by analogues. With caution apply the considered drug to people engaged in hazardous labor, requiring concentration of attention, working with technical devices and mechanisms, driving a car. This is due to the fact that at the initial stage of treatment in half of the patients the drug causes drowsiness, lethargy. The use of Amlodipine in type 2 diabetes does not affect the increase in blood glucose levels. Diabetics take it in the usual way.

 

Posted by Dr.Pressurs in Amlodipine

Amlodipine and diabetes

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Arterial hypertension occurs in diabetic patients approximately 2 times more often than in the general population.

Normalize the pressure in diabetes will help drug “Amlodipine.” Diabetics often face the problem of increased blood pressure, but not all medications can be used with an elevated blood glucose level. “Amlodipine” does not contain components that can influence the sugar, so diabetics can safely take it, after consulting with a doctor.

Why pressure rises with diabetes?

Diabetes mellitus is an endocrine disease characterized by an increase in the level of sugar in the blood and accompanied by various complications, in particular, arterial hypertension. The following factors can contribute to pressure jumps in type 2 diabetes:

  • diabetic nephropathy;
  • intoxication of the body with salts of heavy metals;
  • violation of carbohydrate metabolism;
  • kidney damage;
  • Atherosclerosis and as a consequence narrowing of a large artery;
  • Magnesium deficiency;
  • essential hypertension.

Can “Amlodipine” be taken with diabetes?

To normalize blood pressure in patients with diabetes, often doctors prescribe a medical product “Amlodipine.” The medication relaxes the smooth muscles of the vessels, which, in turn, helps lower blood pressure to normal values. However, the therapeutic actions of Amlodipine do not end there. The described drug reduces the load on the heart muscle, reduces its need for oxygen and minimizes the frequency of angina attacks. Amlodipine does not contain sucrose or another component that could change the concentration of glucose in the blood. Therefore, diabetes mellitus is not included in the list of contraindications specified in the instructions for the drug in question.

Composition and form of release

The main active substance of the drug is amlodipine.

Producers offer potential consumers a tablet form of “Amlodipine”. There are tablets from the active substance amlodipine besylate and such auxiliary components:

  • milk sugar;
  • potato starch;
  • food additive Е572;
  • povidone;
  • monohydrate.

Indications and contraindications

It is advisable to use “Amlodipine” not only for the therapy of high blood pressure, but also for the cure of ischemic myocardial disease, as well as heart disease, manifested by painful sensations in the center of the chest. It should be avoided using tablets to patients who have an individual intolerance or allergic reactions to an ingredient from their composition.

According to the instructions, it is not possible to apply the medication for hypotonic disease, acute disruption of cardiac muscle activity, cardiogenic shock and aortic stenosis. Contraindication is insufficient liver activity, the period of bearing and breastfeeding. “Amlodipine” will harm human health and aggravate the course of the disease if you drink it to patients who have been diagnosed with an acute phase of myocardial infarction.

How to use?

Dosage and duration of the therapeutic course is determined by the attending physician individually for each patient, taking into account the severity of the course of the disease and the characteristics of the patient’s body.

To normalize the blood pressure level in people with diabetes, doctors usually appoint “Amlodipine” in the minimum dosage – 5 mg 1 time per day. With a good tolerance of the drug, the dosage is gradually increased, in parallel observing the reaction of the patient’s body. To achieve the necessary effect from the use of hypotonic medications, it is enough to take 10 mg once a day. For small patients, a safe dose is 2.5-5 mg once a day.

Overdose

In the case of prolonged use of elevated doses of “Amlodipine”, reflex tachycardia, prolonged hypotension, in particular, a shock with a lethal outcome, may develop. Specific antidote does not have medicament. Treatment is symptomatic and is aimed at normalizing the pressure and supporting the activity of the cardiovascular system. The injured person is prescribed calcium gluconate, gastric lavage and activated charcoal intake.

Posted by Dr.Pressurs in Amlodipine, Diabetes

Amlodipine Besylate for Migraines

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Migraine Is One of the most common In the US population, the incidence was calculated to be roughly 250 per 100,000 with a point prevalence of 10 percent. Girls are affected more than men. A number of abortive and prophylactic drugs are being used for therapy and many are being studied in clinical trials. Calcium-channel blockers are used prophylactic drugs. These are the first instances of amlodipine used in migraine prophylaxis.

migraine

But my background: I am For the rest of my childhood and during my early teens, I tried a selection of prophylactic medications (like beta blockers) and symptom-onset remedies, all with minimal if any benefit. My migraines simply “needed to run their program.” I had been administered sedatives through injunction to allow me to maneuver.

Inside my mid-teens, a prescription to Fiorinal Symptom-onset, but with necessitated use I developed a tolerance as well as the benefits along with the rally headaches became more severe. Fiorinal was stopped by me when, also taking the hay and after having been struck with a severe migraine, I opted to visit the Baskin Robbins and underwent a short period of relief. I pledged to not take a narcotic have adhered to this vow and to take care of a migraine.
Tinkering with numerous brands before finally settling on Excedrin (and after Excedrin Migraine as it became available) since the sole, comparatively reliable treatment choice. During post-collegiate and faculty life, despite being advised by experts that as I got older my migraines could eventually become less common and less intense, the opposite occurred. With pressures, the attacks became more regular, more intense and longer-lasting.

There being numerous causes and matters about migraine I Couldn’t control (like the weather, Certain additives or components in meals in pubs, etc), alcohol has been one that I could restrain. So, although I really like the glass of wine or mixed drink and a fantastic beer, I eliminated all alcohol intake. I haven’t had a drink of any type in 18 decades. Do I overlook it?

I’m someone who handles and is aware and averts Them at all prices as soon as possible. A morning or evening in an assault that is inevitable. And, I know when it is going to storm out a hour or 2 prior to the lightning bolt the raindrop or the rumble of thunder. Dependent on the amount of seriousness of my pain, I really could predict the seriousness of a storm compared to the meteorologist with computer applications and the Doppler radar. I was just like a horse at an earthquake zone. Any change within my sleep routine was sure to trigger an attack. Actually, my routine had evolved (or should I say “devolved”) to a circumstance wherein when I slept over 6 hours, I’d awaken in the cries of a full-blown migraine. I have now been subsisting about 5-1/2 hours of sleep each night for the decades. Obviously, I was less than pleased.
Winter and fall to Spring resulted. When I was 34, among these migraines resulted that I suffered for 25 days with no disturbance. I moved throughout this month of hell through multiple bottles of Excedrin.

I dropped 4 headaches in the time. Of Those 16 headaches per month, many were light and / or tolerable (significance, in that I’d grown a high threshold for pain, so I might still work, I might still go to work, etc., however the pain and distress were unthinkable). Normally, 4 or 5 of these 16 per month have been exactly what I’d describe as powerful or acute (meaning that they took multiple doses of OTC meds and generally a while in a darkened, silent room with a ice pack and negatively affecting although not entirely preventing my capacity to operate). Naturally, two or 1 of these 16 migraines a month could be described as inhibiting my ability, lasting and painful and causing lost work days and time together with kids and my spouse. In which I considered myself blessed to have the ability to go 3 times and / or seven times complete in a month with no 37, I got to this stage in my late 30s and 40s.

I had been the poster boy for migraineurs.

However, I titled this “Some Relief later 34 of giggling,” and really I I began experiencing pain, numbness and tingling in my arm. I was in pain and had grown concerned I had been having a heart attack or, in the very least, had an arterial congestion that was likely to require any other heart procedure or a skip. My stress level was high. Upon accepting my vitals, the team in the urgent care clinic told me that they would be not able to assist with the pain in my arm because they were sending me to the emergency room in the hospital. My blood pressure was an 220 over 180. I was on the point of one if I was having a heart attack.

I had been given pain control medicine to my Meds and arm to bring my blood pressure down as quickly as possible. One was imminent had I never sought treatment although an EKG showed I wasn’t using a heart attack.

I had been diagnosed, nevertheless, with moderate hypertension (marginally elevated Blood pressure) that my doctor made a decision to deal with with care meds. The Norvasc is a vasodilator that opens upward blood vessels that are constricted. Because I was 9 years old the Norvasc has supplied my initial noticeable and relief. In the previous 3 decades, I average. I’ve had one headache lasting a day because being discharged from the hospital. Almost for me personallypersonally, was transformative. I am the only person.

Posted by Dr.Pressurs in Amlodipine

How Does Amlodipine Work?

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Amlodipine is a type of drug called a calcium channel blocker, which functions to reduce blood pressure by relaxing the muscles round the blood vessels. Should you or someone you know is getting amlodipine and you’d like to know more about the way that it operates, let’s simply take a closer look.

How does it WORK?

The way that it works IconCalcium is really important in the body and is required to permit some muscles to contract. In particular, smooth muscles that you don’t have any conscious handle over, like these in your heart and that surround your blood vessels, count on on calcium.

Calcium channel blockers like amlodipine block the passage of calcium to the cells. What happens when the calcium is blocked? The muscles can’t contract correctly.


For someone with hyper tension, this is actually a very important thing point. High bloodpressure signifies there is the rest of the cardiovascular system and also too much blood pumping around the physique also fast, putting plenty of stress on the on the heart.

When calcium is blocked from the smooth muscle surrounding the blood vessels when a drug-like amlodipine is taken, the blood vessels expand slightly and relax. This allows the blood to flow through more easily, like placing your hand into a glove the size that is proper, in the place of trying to squeeze it into one that’s a few sizes also little.

Drug Combinations

Amlodipine is also available in combination with other medicines in one tablet, when it is commonly required with specific medications.

All those combination medications is accessible in several doses that are different, s O that each individual can discover the dose suited for them.

Amlodipine and Atorvastatin are available together in an item called Caduet.
Amlodipine and Olmesartan are obtainable together in a product called Sevikar.
Perindopril and amlodipine are accessible together in an item called Reaptan.
Telmisartan and amlodipine are available in an item called Twynsta.
Amlodipine and Valsartan are available in a product called Exforge, or with additional hydrochlorothiazide called Exforge HCT.

What type of drug is it?

Amlodipine is a type of drug called a dihydropyridine calcium-channel blocker. This can be a drug course that aids u-s to group drugs which work in a way that is similar together. Other medications in the same class are:

Diltiazem
Felodipine
Lercanidipine
Nifedipine
Nimodipine
Verapamil

Amlodipine is a unique type of calcium-channel blocker, called a calcium channel blocker. This simply signifies that’s has less on the heart and a mo-Re profound effect on the blood vessels.

What is Amlodipine used for?

The typical use of amlodipine is for some one with hypertension. This is since it operates extremely well to reduce the blood pressure because of the way it works.

Sometimes it might also be used to help people with angina to prevent potential assaults. Usually it’s used in combination with a drug to help avoid clots, like aspirin or clopidogrel with this.

Posted by Dr.Pressurs in Amlodipine

Blood Glucose & Amlodipine

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Amlodipine, marketed under the brand Norvasc, belongs to a class of medicines called calcium channel blockers. Amlodipine is mainly used to treat angina and high blood pressure caused by cardiovascular disease. Amlodipine relaxes blood vessels so the heart doesn’t need to pump as hard. Amlodipine also boosts blood flow to the heart, which relieves chest pain. Amlodipine may affect blood glucose levels.

Blood Glucose and Amlodipine

Amlodipine may cause trigger hyperglycemia, or increased blood-glucose levels, in accordance with Drugs.com. Glucose is the primary source of energy for the body.The body creates glucose in the breakdown of carbs, fats and proteins. High levels of blood glucose can cause injury to blood vessels and body organs. Insulin, a hormone made by the pancreas, helps the body manage blood-glucose levels. Diabetics might have problems, although healthy individuals are able to reduce high blood-glucose levels caused by amlodipine. Amlodipine should be used cautiously in patients with diabetes.

blood sugar

Symptoms of Hyperglycemia

Patients with a blood glucose level higher than 160 mg/ dl. Amlodipine causes short-term hyperglycemia. Blood sugar levels levels return to normal when the drug is discontinued. Symptoms of hyperglycemia triggered by amlodipine contain increased thirst, frequent urination, increased hunger, blurred vision. Chronic hyperglycemia is common in patients with diabetes.

Amlodipine Administration

Amlodipine is available as an oral tablet that is taken once daily. Amlodipine needs to be taken around the same time each day. Diabetics should check their blood glucose amounts before and after using amlodipine. Patients getting amlodipine should know the indicators of hyperglycemia and report them for their doctor.

Side Effects of Amlodipine

Patients taking amlodipine might encounter common facet results for example headache, dizziness, drowsiness, flushing, upset abdomen and extreme exhaustion, according to Drugs.com. Other unfavorable effects of amlodipine contain swelling of the palms, feet, ankles and lower legs; fast, pounding heartbeat; fainting; chest discomfort and discomfort that spreads to the arm or shoulder. Patients who experience these signs should seek immediate medi cal help.

Posted by Dr.Pressurs in Amlodipine